She said disruptive innovation - ideas that create a new market or value network at the expense of an existing one - could start as gradual incremental advances that were shown in the longer term to be ground-breaking. Between the health care that we have now and the health care that we could have lies not just a gap, but a chasm.1 In certain situations, innovation challenges are rejected directly because they are seen as threats to the means of support and character of many stakeholders, such as pharmaceutical companies, Federal regulatory institutions and the American Medical Association, that deploy an intangible but forceful influence on decision-making. (2014), Munos, B. and Chin, W. “How to Revive Breakthrough Innovation in the Pharmaceutical Industry.” Science Translational Medicine. If you continue to use this site we will assume that you are happy with it. Google Apps changed the industry through the use of free online integrated document sharing. Disruptive technologies and seminal therapies will significantly advance medical care … A broad range of promising and disruptive technologies such as 3-D printing, nanotechnology, bionics and predictive analytics as well as seminal new treatments like genetics, cellular programming and stem cell therapies are starting to have an impact on today’s medical care. DTC in Perspective: Entresto Is Interesto! Future: Multi-Dimensional Patient Centricity. But it needs to act now in order to stay in business when the tsunami of disruptive technologies reaches us. Asking controversial questions that confront existing knowledge of the industry; Thoroughly examining behaviors to identify new ways of doing things; Encountering people with fundamentally dissimilar ideas and perspectives; Building interactive experiences that trigger non-traditional responses to discover what insights emerge; and. The end res… While many examples of disruptive innovation and technology across industries abound, it is significantly underutilized within the pharmaceutical industry. Since 2000, for instance, more than $200 billion has been poured into healthcare venture capital, mostly in biotech, pharma and devices, important treatments … Connecting the dots with questions, issues or ideas from unrelated fields. These 10 technologies will transform Pharma and we need to act now to reap the rewards in order to stay in business when they reach us. “Disruptive Innovation Theory Revisited.” Innovation Excellence. In general, those involved in the drug discovery and development enterprise are open to change in order to achieve greater success, but there are variations in what that change will look like, and the NAM paper describes three very different versions of the future. The first vision suggests that the pharmaceutical industry go as far as shifting its focus entirely to healthcare delivery versus drug discovery and development, given all its accumulated knowledge in patient-centric issues. After 30 years of successful usage in Europe, the jolting factor of antiseptic surgery acceptance in the United States is attributed to the almost assuredly avoidable death of President James Garfield. 2007;13(4):10-14.) 2 Linda is a researcher/writer for the Public Health Museum and a member of the American Public Health Association and American Association for the History of Medicine. There is also a great deal of risk to companies choosing to take on innovative and potentially disruptive approaches. NewAmsterdam Pharma raises $196m through Series A funding round, FDA approves Pfizer’s Xalkori in ALCL in children, young adults, SII expects WHO emergency approval of Covid-19 vaccine soon, Phesi and Sensyne to collaborate on synthetic control arms for clinical trials, Biden unveils Covid relief plan to stimulate US economy – leading macroeconomic influencers, Genomics and Covid-19: UK’s real-time surveillance system to track viral mutations, AzurRx engages CROs Rho and Linical in separate Phase II trials in cystic fibrosis with pancreatic insufficiency, Revitope Oncology welcomes CRO and CMO pitches in several months for Phase I trial and drug development, GlobalData Epidemiologist Report: Grim milestone reached as global Covid deaths exceed 2 million, Disease-cancelling drugs: Immuneering raises $62m in Series B round, A standard approach to drug development for accessing the globe, Biopharma M&A: EY analysts optimistic for 2021 deals after a mixed 2020. It has three distinctions. Mariano Maluf, Disruptive Innovation @NCR | Ex-CocaCola, HomeDepot, BellSouth, GTE/Claro, GNAX Health at NCR Corporation 4 years ago Emma Bellantonio Goncalves , Inbound marketing manager chez Opéra Energie at Opéra Energie Contributed by: Denise Myshko. This can be viewed through two different lenses: 1) the dynamics of the local healthcare environment and homegrown innovators and 2) through disruptive innovation (a model first formulated by Innosight co-founder Clay Christensen). A culture of innovation is what we need to be building. In reality, it is extremely risky. In turn, this would leave the space wide open for unimpeded innovative disruption of the drug discovery and development enterprise. A disruptive innovation helps create a new market and value network. Disruptive Innovations are NOT breakthrough technologies that make good products better. If we look at innovation versus effort, we can identify three zones and three types of innovation… One of the key issues to consider, however, is whether the innovative forces will come from within or outside of the industry (internal versus external disruptors). Clay Christensen pioneered the principle of disruptive innovation, which is defined as “an innovation that creates a new market by applying a different set of values, which ultimately (and unexpectedly) overtakes an existing market.” 2 The role of disruptive innovation 4 Disruptive Innovations in Healthcare Mark A. Hyman, MD, is the editor-in-chief of Alternative Therapies in Health and Medicine. Recent studies with marginal drugs show a 50% failure rate due to a lack of efficacy or safety. A paper presented to the National Academy of Medicine (NAM) in July 2016 summarized the results of interviews with 25 leaders from various sectors of the drug development industry, including the strengths and weaknesses of the prevailing model, opinions on future paradigms, and how to achieve transformation in the industry. When an industry undergoes a radical change because of the entrance of a disruptive technology, those too cumbersome to move fast enough, too conservative to move far enough, or too complacent to believe they need to move at all may find themselves clinging to … More importantly, it frees innovators from the rigid adherence to the ‘new pill’ framework and objective. Coronavirus company news summary – Switzerland approves Moderna’s Covid-19 vaccine – US HHS and DOD secure supply of Regeneron’s antibody drug cocktail for hospitalised Covid-19 patients, Coronavirus company news summary – NeuroRx, Relief and Quantum Leap team up on I-SPY Covid-19 trial – Indonesia approves Sinovac’s Covid-19 vaccine, Coronavirus company news summary – UK approves Moderna’s Covid-19 vaccine – COVAXX starts studying a new vaccine that tackles emerging viral mutations and variants, Company coronavirus news summary – CureVac teams up with Bayer to support its Covid-19 vaccine – Bharat Biotech completes recruitment for its Phase III vaccine trial. Christensen makes it very clear that ‘disruptive innovation’ is not a ‘breakthrough’ innovation. But in the spirit of creative approaches, companies find funding solutions and ways to mitigate costs with other enterprises, from government to other private entities and even individuals with available resources. 13, NO. Lessons learned from the past indicate that attitudes impacted the resistance to effective existing pharmaceuticals. (2013), “Growing the Pipeline, Growing the Bottom Line: Shifts in Pharmaceutical R&D Innovation.” KPMG Pharmaceutical R&D Innovation. We use cookies to ensure that we give you the best experience on our website. Disruptive Innovation Defined. Disruptive Technology: The Keys to Pharmaceutical Innovation. Considering what is at stake and the scale of the undertaking, it would seem there is room for a variety of industries to bring value to the enterprise. Resistance to change in pharma emanates from industry incumbents whose jobs rely on sustaining the existing business model and political power. The innovation eventually disrupts an existing market and value network. October 11, 2012 Thomas Krohn, Director, Eli Lillys Clinical Open Innovations thoughts on Dpharm 2012. Clayton M. Christensen is a professor at Harvard Business School and the term ‘disruptive innovation’ and its definition was developed by him in his book ‘The Innovator’s Dilemma’. In the book “The Innovator’s Prescription: A Disruptive Solution for Health Care,” Clay Christensen, who developed the theory of disruptive innovation, stated, “There are more than 9,000 billing codes for individual procedures and units of care. All Rights Reserved. Linda J. DiPersio, MSM, MSHC, is a professional writer. Disruptive innovation is a concept that has been developed for analysing ways to improve health outcomes and reduce costs in the US health care system. NOTE: The content below contains the first few paragraphs of the printed article and the titles of the sidebars and boxes, if applicable. In the future, the drug lifecycle needs to incorporate many facets of patient centricity, including the use of new technologies such as gene- and proteomics, gene therapy, nanotechnology, and Big Data driven predictive analytics. The agent of this transformation is disruptive innovation. Furthermore, in-kind utilization of disruptive innovation within the pharmaceutical industry, while serving initially as a bane to some of the more well-established companies, could eventually prove to be the panacea urgently needed for greater success in developing therapies to treat and prevent human disease. Disruptive Innovation in Pharma – Time to get on board! Yet most of the innovation that has occurred has been sustaining to the industry rather than disruptive. Disruptive innovation. (2011). About the author: A variety of studies have documented the need for innovative approaches and disruptive technologies to rescue the currently stagnant drug discovery and development enterprise. Creativity that changes behavior will be framed by: In summary, the past and present challenges mapped out on the spectrum provide valuable information that will shape future disruptive innovation in a beneficial way. There are no pre-competitive consortiums to divide the challenges and costs of developing new knowledge about disease causation. As Upton Sinclair said, “Never expect someone to understand change when their livelihood depends on not understanding it.”. DTC in Perspective: The Media Bias Against DTC. Conversely, disruptive innovation describes a new business model but not necessarily a technological breakthrough. In the pharmaceutical industry, disruptive innovation improves health by generating ideas that create new drugs at the expense of existing ones. It is an alliance between technological advances and new business models that dramatically changes the performance of the industry. Today, innovation is distributed over a group of partners with universities conducting the riskier early translational research and pharma investing in late development with perceived low risk. Subscribe to our e-mail newsletter to receive updates. It is an alliance between technological advances and new business models that dramatically changes the performance of the industry. Clinical Research Services for Early-Stage Biotech Companies, eCRF and Custom Web Platforms for Patient Data Collection and Clinical Trial Management, Contract Analytical Chemistry Services and Quality Control Testing, 2 March 2017 (Last Updated March 2nd, 2017 04:56). There is no doubt that disruptive innovation in a variety of industries has met with high levels of success, with the eventual adaptation of the more firmly entrenched companies to this approach. One of the key tenets of disruptive innovation is that it often starts small. Currently, pharma believes that marginal innovation is actually “safe” disruptive innovation because it is supported by confirmed targets, proven forms of action and/or established drug classes. Senior executives responsible for shaping and driving overall corporate and digital strategy will benefit from attending this programme. The second vision describes a more conventional disruption, that of employing technologies that will be paradigm shifting for medicine and clinical research, while the third addresses the emergence of a new and complex ecosystem arising from a new and innovative business model in the industry. Linda earned a Master’s in Health Communication from Boston University and a Master’s in Management from Lesley University. Safer trials, which are designed to add evidence-based support of the versatility of top drugs, take away the amount of funds from innovations and discovering new cures. Despite the remarkably positive success of antiseptic surgery with carbolic acid saving many lives during active combat in late 19th century Europe, Surgeon Dr. Samuel Gross from the United States said, “Little, if any faith, is placed by any enlightened or experienced surgeon on this side of the Atlantic in the so-called carbolic acid treatment of Professor Lister.” The medical community in the United States not only disapproved of the concept of germ theory that promoted the protection of patients against airborne microbes, and any drug associated with it, but also they fully rejected it – instead believing that miasma or bad air caused infection. His non-life threatening gunshot wound from an assassination attempt was cared for by a team of doctors with germ-laden contact, including non-sterilized instruments, which lead to a major infection most likely being the cause of death. Here Lewis-Hall cited Pfizer's Lipitor and the drug's influence in reducing cardiovascular disease death rates. Reverse innovation is a response to numerous challenges, that Pharma Industry is facing now: such as a slowdown in successful innovations, increasing research costs, decreasing revenues due to patent expirations, and the huge expense to bring a drug to the market as a result of enhanced regulatory hurdles. Insights derived from the right data are at the forefront of this, tying together trends in mobile health, wearables, regulatory needs and even innovative approaches to partnerships. Then at some point, the industry is transformed; the products or services become simpler, easier to use, and much more convenient and affordable. (Altern Ther Health Med. The companies that innovate the most, the fastest and the most successfully have created cultures that enable, reinforce and reward innovation. Beginning as low risk, low returns and low R&D, cautious analytics eventually equate to bad risk with ill-fated consequences. Pharmaceutical Marketing Conference Leaders, In the News: Abuse-Deterrent Formulations Stirring Up the 2016 J.P. Morgan Pharmaceutical Conference, Pfizer, BioNTech Announce Final Efficacy Analysis from Phase 3 Study of their COVID Vaccine Candidate, The Independence of COVID-19 and Patient Traffic Trends, Three Things That Make Your Brand Patient Ready, 5 Ways COVID-19 Affects Community-Based Organizations, Increasing Medication Adherence with Multi-Channel Communications, Print: Alive and Well at the Point of Care. Read these five examples, which will help you understand the concept of disruptive innovation better. In the future, leading the way with a multi-dimensional, patient-centric approach to the drug pipeline will allow for increased profits and improved health outcomes. Disruptive Innovations have led to a whole new market shift with the public, focusing more towards the streams than ever before. For example, Google Apps is a disruptive innovation (game changer), while Pfizer, the world’s biggest pharmaceutical company (by revenue), is an example of sustaining innovation. In this interview, part of our Biopharma Frontiers series on how the pharmaceutical industry is evolving and how leaders can adapt, Epstein discusses the next horizon of innovation, critical elements of an effective business, and the kind of culture he tries to foster. Sustaining vs disruptive Innovation “Disruptive innovation” is a powerful concept coined by Harvard Business School Professor Clayton Christensen, and has been in play in a variety of industries such as high tech, with the introduction of personal computers and cell phones initially, followed by the mobile internet, the cloud, and the internet of things, as well as in medicine, with the opening of medical clinics, competing with traditional doctor … (2013), Coleman, D. “The DNA of Disruptive Innovators: Will Pharma be Disruptors or Disrupted?” Eye for Pharma. (2014), “Disruptive Innovation and the Future of the Drug Lifecycle.” PhRMA. “Disruption” describes a process whereby a smaller organization with few resources is able to successfully challenge a larger well-established organization (Christensen, Raynor, & McDonald, 2015), and it has recently been heralded as a way to control health care spending in the United States (Hwang & Christensen, 2008), although there are relatively few medical providers who are familiar with the … Directors, vice presidents, senior managers and project team members who are responsible for formulating and driving innovation, and transformation strategies across business units, products and functions will gain valuable skills and tools. Presently, with pharma’s perception of “safe risks,” engaging in cautious analytics eventually results in bad risks. How much are your pharmaceutical shipments really costing you? However, the introduction of a threat to the continued success of a few established companies may actually have the effect of prompting these companies to join in on the use of disruptive innovation. New social media tools will allow patients to share information and participate in collaborative discussions with regulators and pharma. She has been published in the Journal of Communication in Healthcare. The Expert Panel on Effective ways of Investing in Health (EXPH) was requested to focus on the implications As the above example shows, the advancement of pharmaceutical innovation efforts are most often prevented by established world views, opinions, customs, attitudes, societal values and complex psychological and emotional issues ingrained in the network of relationships that define individuals singly or collectively. She is the author of psychological, pharmaceutical and historical health information on her website: www.health-savvy-with-Linda-DiPersio.com. “Disruptive innovation” is a powerful concept coined by Harvard Business School Professor Clayton Christensen, and has been in play in a variety of industries such as high tech, with the introduction of personal computers and cell phones initially, followed by the mobile internet, the cloud, and the internet of things, as well as in medicine, with the opening of medical clinics, competing with traditional doctor office practices. In almost every industry, the products or services that are offered initially are so complicated and expensive that only people with a great deal of money or skill can afford or use them. Currently, she is pursuing a Doctor of Psychology (PsyD) degree at California Southern University. If pharma practices the five skills of questioning, observing, networking, experimenting, and associating that are outlined in the book “The Innovator’s DNA” authored by Gregersen, Dyer, and Christensen, disruptive innovation will be constructively delivered, empowering patients, and effecting positive change through physicians who will proactively treat and potentially prevent illnesses before they become a major source of concern. The progressive spectrum of disruptive innovation challenges include lessons from the past showing resistance to change, implications surfacing in the present which emerge from cautious analytics and trailblazing dynamics in the future aligned with patient centricity. It embraces new ideas and new solutions. The safe bet is the unsafe bet when it comes to disruptive innovation. Marginal pharmaceutical compounds have a high risk of not achieving end results, not being accepted by regulators and/or not performing up to the standards of existing less costly therapeutics and fail commercially. Precision medicine will identify exact patient needs and tailor molecular profiles to create the most beneficial treatment plans for patients on an individual level. © 2021 DTC Perspectives. But there is not a single billing code… for helping patients stay well.” In the pharmaceutical industry, disruptive innovation improves health by generating ideas that create new drugs at the expense of existing ones. 2The term “disruptive innovation” is defined here as a transformation of the pharmaceutical industry driven by new technology, new business models, or policy decisions that improve therapy and create value for patients and society in a way that could not be achieved through other means. These 10 technologies will transform Pharma and we need to act now to reap the rewards in order to stay in business when they reach us. The pharmaceutical industry is still in time to reap rewards too. The flip side of any new paradigm-shifting disruptive innovation is that it could be somewhat disadvantageous to already well-established companies in the industry and generate resistance. Disruptive innovations create new markets for products or services, or they reshape existing markets. 10 ALTERNATIVE THERAPIES, jul/aug 2007, VOL. “Disruptive Innovation” was coined in the early 1990s by Harvard Business School professor Clayton Christensen (who passed away last week), the term has become virtually ubiquitous from Wall Street to Silicon Valley. As Clayton Christensen said, “Disruptive innovation is a positive force.”, Christensen, C., Hatkoff, C. and Kula, I. 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